REGENERATION OF A MOUSE HEART AFTER A HEART ATTACK.

Researchers studied, and are still studying, animals like zebrafish, which cut off 20% of the heart recovers smoothly, because of his fascinating regenerative capacity. One option is to use stem cells, but in the laboratory of Juan Carlos  Izpisúa managed a mouse hart recover completely after myocardial infarct.

When they blocked four molecules in particular, the researchers observed a great improvement in healinge and regeneration in mice. This produced that heart cells returned to a pioneering position that allowed them proliferation in tissue.

The team decided to focus on microRNAs and made a comprehensive screen for microRNAs that were changing their expression levels in the healing phase in the fish (which is also found in mammals). The studies showed four specific molecules that fit their criteria. All were suppressed during cardiac injury in zebrafish. However, in studies with mammalian cells, the researchers observed that these were abundant and not reduced to the injury. So the team used a specific virus for finish with these microRNAs.

The introduction of these viruses in the hearts affected sparked a regeneration of cardiac cells which in turn produced a physical and functional improvement at heart. The improvement was visible between three and six months later.

The next step is explore with bigger animals and with bigger hearts and also an alternative method to virus.

This is a breakthrough as they continue to explore and we could reach a point where we are able to heal ourselves without implanting cells coming from outside of our body.

In the original article also say that besides the molecules there are also proteins as regulators like cardiomyocytes that play an important role in the regeneration.

This picture is of a heart muscle cells after regeneration treatmentA.

 

OPINION:

I chose this subject because I find it very interesting because we could solve many problems in the future but it could also create much controversy. The fact that in the future we could regenerate all mammals mean an enormous scientific and social evolution. Moreover the fact experimenting with genes could cause many problems because being such a sensitive topic, a little mistake could mean disaster.

ARTICLE FROM SALK:

http://www.salk.edu/news/pressrelease_details.php?press_id=2058

Other sources (from EL PAÍS):

  http://elpais.com/elpais/2014/11/04/ciencia/1415060356_887155.html

ORIGINAL ARTICLE: 

   http://www.sciencedirect.com/science/article/pii/S1934590914004548

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Estas entrada foi publicada en Biología animal, Bioloxía celular, Curso 2014-2015 coas etiquetas , . Ligazón permanente.

2 Responses to REGENERATION OF A MOUSE HEART AFTER A HEART ATTACK.

  1. Fascinating discovery!, “It’s a strange sounding idea, since we associate regeneration with salamanders and fish, but not mammals”, commented a member of the research group (Salk Institute News Release). I propose that link because you can find there almost first-hand information, and it is in English!

    You seem to have some troubles with your English writing:
    > Sometimes I find there are missing words. So , “Izpisúa managed a mouse recover completely after myocardial”, must be : Izpisúa managed a complete heart recover after myocardial infarct.

    > The second paragraph remains obscure, even though you try to explain there the main ideas in the experimental procedure, as well as their major results. The last clause is the worse: “Before the process responsible for this four genes were detected, and after doing a test on a picture, made directly on the scar.” This may be a senseless translation for:

    “Consiguieron modificar primero -los genes- in vitro, para comprobar que las células del corazón se recuperaban (en la imagen) y posteriormente in vivo, directamente en la cicatriz que dejaba el infarto en el corazón de un ratón adulto”
    They haven’t done any test on a picture, simply the journalist is telling us that this process (the cells dedifferentiation) can be seen in one of the images provided.

    As everyone could probably agree, it is not clearly written in Spanish, and you’ve misunderstood it. Maybe the caption of this image in the News Release can help: “In a dish, heart muscle cells return to a precursor-like state (…)”, being “in a dish” the English popularization expression for the technical latin term “in vitro”.

    >> By the way, you should use the information in this caption to improve yours. Remember that, when you edit the image, the text must be written in the “legend” frame, so the caption will have a suitable format. You have this picture with better resolution here (you could insert that link behind your image).

    In my opinion, you haven’t selected properly the main ideas from the original source, You can easily find them in the ‘Highligts’, and in the ‘Graphical Abstract’ provided. Certainly, they haven’t manipulated genes, as it is erroneously suggested in El País. So, what have they done?. Explain it better!.
    >> Besides that, when you compare the primary an the secondary sources, you say “and secondary items only speak mouse without generalizing”. But, have you read the title in the press article?.

    • Iraima Fernández di:

      I have modified the article and also the source because the article from “El País”, in my opinion after have seen the article from Salk News Release, was uncompleted and bad explained.

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